Neural crest cells are multipotent progenitors, capable of producing diverse cell types upon differentiation. Recent studies have identified significant heterogeneity in both the fates produced and genes expressed by different premigratory crest cells. While these cells may be specified toward particular fates prior to migration, transplant studies show that some may still be capable of respecification at this time. Here we summarize evidence that extracellular signals in the local environment may act to specify premigratory crest and thus generate diversity in (...) the population. Three main classes of signals–Wnts, BMP2/BMP4 and TGFβ1,2,3–have been shown to directly influence the production of particular neural crest cell fates, and all are expressed near the premigratory crest. This system may therefore provide a good model for integration of multiple signaling pathways during embryonic cell fate specification. BioEssays 22:708–716, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

[Open access] In this book symposium the author takes up questions from phenomenology, hermeneutics, ethical theory, and intellectual history raised by a group of scholarly interlocutors from a range of backgrounds. In the course of engaging with these issues, he discusses, inter alia, McDowell’s realism, Jonathon Lear’s work on the end of a world, Michael Oakeshott’s view of selfhood, Heidegger’s conception of Jemeinigkeit, Uexküll’s notion of Umwelt, and Gadamer’s hermeneutic conception of truth.

This paper defends Parfit's "theoretical" view of personal identity against Christine Korsgaard's objections grounded in practical identity.

David Miller elegantly and provocatively reformulates critical rationalism—the revolutionary approach to epistemology advocated by Karl Popper—by answering its most important critics. He argues for an approach to rationality freed from the debilitating authoritarian dependence on reasons and justification. "Miller presents a particularly useful and stimulating account of critical rationalism. His work is both interesting and controversial... of interest to anyone with concerns in epistemology or the philosophy of science." —Canadian Philosophical Reviews.

"In the first study of its kind, David W. Johnson's "Watsuji on Nature" reconstructs the astonishing philosophy of nature of Watsuji Tetsurō (1889-1960), situating it in relation both to his reception of the thought of Heidegger and to his renewal of core ontological positions in classical Confucian and Buddhist philosophy. Johnson shows that for Watsuji we have our being in the lived experience of nature, one in which nature and culture compose a tightly interwoven texture called "fūdo". By fully (...) unfolding Watsuji's novel and radical claim that this is a setting that is neither fully external to human subjectivity nor merely a product of it, this book also sets out what still remains unthought in this concept, as well as in the relational structure that underwrites it. Johnson argues that what remains unarticulated is nothing less than the recovery of a reenchanted conception of nature and an elucidation of the wide-ranging implications of a relational conception of the self for questions about the disclosive character of experience, the distinction between fact and value, and the possibility of a place-based ecological ethics. In an engagingly lucid and deft analysis, "Watsuji on Nature" radically expands our appreciation of twentieth-century Japanese philosophy and shows what it has to offer to a global philosophical conversation"--Provided by publisher. (shrink)

Before being able to answer key practical questions dependent on a criterion of personal identity (e.g., am I justified in anticipating surviving the death of my body?), we must first determine which general approach to the issue of personal identity is more plausible, reductionism or non-reductionism. While reductionism has become the more dominant. approach amongst philosophical theorists over the past thirty years, non-reductionism remains an approach that, for all these theorists have shown, could very well still be true. My aim (...) in this paper is to show that non-reductionism is actually either irrelevant---with respect to the practical questions we want answered---or logically impossible. In arguing for this conclusion, I draw from a case Derek Parfit has employed---the CombinedSpectrum---and I provide a number of variations to it which ultimately reveal that we have no possible rational recourse other than to become reductionists. (shrink)

David Miller is the foremost exponent of the purist critical rationalist doctrine and here presents his mature views, discussing the role that logic and argument play in the growth of knowledge, criticizing the common understanding of argument as an instrument of justification, persuasion or discovery and instead advocating the critical rationalist view that only criticism matters. Miller patiently and thoroughly undoes the damage done by those writers who attack critical rationalism by invoking the sterile mythology of induction and justification (...) that it seeks to sweep away. In addition his new material on the debate on verisimilitude is essential reading for all working in this field. (shrink)

This issue 23 of FICHTEANA is dedicated to Daniel Breazeale, who passed away on 30 December 2023. -/- "FICHTEANA Review of J.G. Fichte Research" is an annual online publication in English devoted to new scholarship on the philosopher Johann Gottlieb Fichte. It publishes information and reviews of the latest Fichte editions, books, publications, conferences, and Calls for Papers. Originally founded by Daniel Breazeale in 1993, since issue 22 (2022), FICHTEANA has appeared in an expanded form with book reviews. Editors: Daniel (...) Breazeale (†) and David W. Wood; with associate editors Kienhow Goh and Gesa Wellmann. -/- . (shrink)

Attacks nothing less than the currently prevailing worldphilosophy--humanism, which the author feels is exceedingly dangerous in itshidden assumptions.

David Hume's writings on history, politics and philosophy have shaped thought to this day. His bold scepticism ranged from common notions of the 'self' to criticism of standard theistic proofs. He insisted on grounding understandings of popular religious beliefs in human psychology rather than divine revelation, and he aimed to disentangle philosophy from religion in order to allow the former to pursue its own ends. In this book, Professors David W Purdie and Peter S Fosl decipher some of (...) Hume's most challenging texts for the modern reader, while preserving the sharp intellect and undaunted nerve for which Hume is famous. Hume's spirit is brought alive for contemporary times and his writing is made accessible for its intended audience: the general public."-- Back cover. (shrink)

This paper attempts to reconcile two ideas that seem fundamentally opposed to one another: the reality of the self and the doctrine of no-self. Buddhism offers a form of spiritual equanimity that turns on the denial of a self. Nonetheless, there seem to be good reasons to hold onto the reality of the self. The existence of a self enables us to account for praise and blame, the hopes for oneself that motivate actions, and attachments to the selves of others (...) in bonds of love and affection. I show how it may be possible to reconcile the reality of the self with a particular interpretation of the no-self doctrine by engaging with the work of thinkers from the phenomenological tradition such as Merleau-Ponty, Zahavi, Gallagher, and Petitmengin. (shrink)

This article focuses on the occasional individuals of many species that live longer than is usual for their populations – here called longevity outliers. They appear to be exceptions to the usual patterns of mortality rates that increase with age. There is no model of survivorship that accommodates all of these individuals. They are less vulnerable to the usual causes of death than most in their populations. There are hints of genetically based mechanisms in the form of life‐prolonging genes in (...) invertebrates and genetic resistance to fatal diseases in higher organisms. The reasons why longevity outliers ultimately die are not known. Based on well‐established trends, I predict that there will be many more humans reaching very old ages in the next century. (shrink)

In this paper, I attempt to show that the moral/conventional distinction simply cannot bear the sort of weight many theorists have placed on it for determining the moral and criminal responsibility of psychopaths. After revealing the fractured nature of the distinction, I go on to suggest how one aspect of it may remain relevant—in a way that has previously been unappreciated—to discussions of the responsibility of psychopaths. In particular, after offering an alternative explanation of the available data on psychopaths and (...) their judgments of various sorts of norm transgressions, I put forward a hybrid theory of their responsibility, suggesting how they might be criminally responsible, while nevertheless failing to meet the conditions for an important arena of moral responsibility. (shrink)

Remarks to the effect that a correct answer depends upon a correct question —that from a misleading question there can result only a misleading answer—are common today. In fact, one might suspect that such common concentration on finding the right questions has something to do with what seems to be an uncommon lack of answers. This concentration on the importance of asking the right questions can be applied to the interpretation of biblical literature. For here, certainly, the questions asked are (...) often decisive. They guide the inquiry by setting the terms of the search and, in this sense, they determine at least the kind of answers that will be given. Further, they often disclose the presuppositions with which one is working. (shrink)

Aron Gurwitsch’s theory of the structure and dynamics of consciousness has much to offer contemporary theorizing about consciousness and its basis in the embodied brain. On Gurwitsch’s account, as we develop it, the field of consciousness has a variable sized focus or "theme" of attention surrounded by a structured periphery of inattentional contents. As the field evolves, its contents change their status, sometimes smoothly, sometimes abruptly. Inner thoughts, a sense of one’s body, and the physical environment are dominant field contents. (...) These ideas can be linked with (and help unify) contemporary theories about the neural correlates of consciousness, inattention, the small world structure of the brain, meta-stable dynamics, embodied cognition, and predictive coding in the brain. (shrink)

In this paper we study abstract elementary classes using infinitary logics and prove a number of results relating them. For example, if is an a.e.c. with Löwenheim–Skolem number κ then is closed under L∞,κ+-elementary equivalence. If κ=ω and has finite character then is closed under L∞,ω-elementary equivalence. Analogous results are established for . Galois types, saturation, and categoricity are also studied. We prove, for example, that if is finitary and λ-categorical for some infinite λ then there is some σLω1,ω such (...) that and contain precisely the same models of cardinality at least λ. (shrink)

In our age of globalization, we need a theory of global management consistent with our common human nature. The place to begin in developing such a theory is the philosophy of traditional cultures. The article focuses on African philosophy and its fruitfulness for contributing to a theory of management consistent with African traditional cultures. It also looks briefly at the Confucian and Platonic-Aristotelian traditions and notes points of agreement with African traditions. It concludes that the needed theory of global management (...) should regard the firm as a community, not a collection of individuals, and should understand the purpose of management as promoting the common good. (shrink)

A new era is at hand: the era of sustainable superabundance. In this era, the positive potential of humanity can develop in truly profound ways. It is time for transhumanists around the world to step up to the responsibility as catalysts of the forthcoming transformation.

This paper is a combination of a grandfather's musings over his grandson's drawings, combined with a reconsideration of hermeneutics as an early childhood educational theory.

This article examines Engelhardt’s thesis from the standpoint of liturgical theology. Fagerberg’s previous work has claimed that liturgy gives birth to theology in such a way that liturgy is the ontological condition for theology, as Schmemann said. If we apply this approach to the question at hand, we will understand liturgy to be the source and foundation also for Christian morality. This is no particular surprise, since the Christian tradition has always integrated liturgy, theology, and asceticism, that last named treating (...) morality as a pathway to deification. Liturgical theology views liturgy as a pneumatic exercise that makes theologian souls, and liturgical asceticism understands such theologian souls to be molded by the doings of the body, and this delivers us to the threshold of liturgical morality, for in liturgy the God’s-eye perspective shares its light with us. (shrink)

This paper articulates and defends a noncognitive, care-based view of identification, of what privileged psychic subset provides the source of self-determination in actions and attitudes. The author provides an extended analysis of "caring," and then applies it to debates between Frankfurtians, on the one hand, and Watsonians, on the other, about the nature of identification, then defends the view against objections.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Painting Outside the Lines: Patterns of Creativity in Modern ArtMatthew ZiffPainting Outside the Lines: Patterns of Creativity in Modern Art, by David W. Galenson. Cambridge: Harvard University Press, 2001, 272 pp., $29.95.The relationship between the market value of paintings and the chronological point in an artist's working life when the paintings were produced is the driving mechanism for exploring creativity and innovation in David W. Galenson's (...) book "Painting Outside the Lines: Patterns of Creativity in Modern Art. The working thesis of this book is that Modern artists have worked creatively and innovatively in one of two distinctly different manners. The terminology Galenson uses to describe these distinct ways of working are "finders" and "seekers." Finders are artists like Pablo Picasso, who at age 26, make startling and important innovations with little advance indication that such a burst is about to take place. Seekers are artists like Paul Cezanne, whospend their entire working lives engaged in the pursuit of a singular approach or achievement. The differences between these methodologies are carefully presented through the details of the working lives of a variety of Modern artists. French nineteenth century and early twentieth-century artists and mid-twentieth-century American artists are used as the source data for these comparisons.Early in the book Galenson presents lists of chronological events within the lives of artists and market valuation of their work within this chronology. The dramatic clarity of the relationships presented in this data sets the stage for the detailed information that follows. Factors that in some cases only partly, and in others nearly completely, explain an artist's way of working are offered through biographic information, information about the aesthetic and cultural milieu, and about the economic and educational structures that are predominant during the relevant time in the life of the artist.The relationship between the aesthetic and cultural milieu surrounding an artist and the capacity or inclination of an artist to be innovative is an important aspect of the book's analysis. The scope of the book is limited to Modern artists because of the shift that took place at the outset of Modern art, during the mid 1860s, that brought a strong emphasis on innovation and change for their own sake as an important characteristic within a work of art. This emphasis "created incentives for painters to produce new approaches to art" (p. 111). Prior to the time of Modern art, innovation and change were often unnecessary for an artist to be successful. Modern art introduced the demand that innovation and change be necessary ingredients in art, and therefore the search for innovation became a significant element within the work of many artists. The manner in which this search took place, as presented through the data at hand, reveals how individual artists viewed the need for innovation and change within their own [End Page 123] work. Paul Cezanne, for example, was aware of the impact that his painting was having on the art world, but he insisted that he was not yet finished with discoveries that would reveal the truest expression of his beliefs about aesthetic expression.In the American movement, "Abstract Expressionism," Galenson finds a useful counter example to the art scene in Paris. In the United States, especially during the 1940s and 1950s — the peak years of creative output by Abstract Expressionist artists — the demand for their work was quite low. There were few economically viable outlets for the work of de Kooning, Pollack, Rothko, and the others of this group. Consequently there is a shift in the chronological point at which these artists achieve market value success. Nearly all of these artists receivedrecognition at an older age than the French artists of the late nineteenth and early twentieth centuries.The thesis of the book, that there are two fundamentally different ways of working to produce works of art, is directly applicable to, and useful in, exploring issues of teaching and learning in design education. As a teacher of interior architecture I was interested to follow the details that Galenson presented in support of his analysis of the careers of numerous Modern artists. The methodological differences between seeking and... (shrink)

This is an in-depth study of J.G. Fichte’s philosophy of mathematics and theory of geometry. It investigates both the external formal and internal cognitive parallels between the axioms, intuitions and constructions of geometry and the scientific methodology of the Fichtean system of philosophy. In contrast to “ordinary” Euclidean geometry, in his Erlanger Logik of 1805 Fichte posits a model of an “ursprüngliche” or original geometry – that is to say, a synthetic and constructivistic conception grounded in ideal archetypal elements that (...) are grasped through geometrical or intelligible intuition. -/- Accordingly, this study classifies Fichte’s philosophy of mathematics as a whole as a species of mathematical Platonism or neo-Platonism, and concludes that the Wissenschaftslehre itself may be read as an attempt at a new philosophical mathesis, or “mathesis of the mind.” -/- “This work testifies to the author's exact and extensive knowledge of the Fichtean texts, as well as of the philosophical, scientific and historical contexts. Wood has opened up completely new paths for Fichte research, and examines with clarity and precision a domain that up to now has hardly been researched.” Professor Dr. Marco Ivaldo -/- “This study, written in a language distinguished by its limpidity and precision, and constantly supported by a close reading of the Fichtean texts and secondary literature, furnishes highly detailed and convincing demonstrations. In directly confronting the difficult historical relationship between the Wissenschaftslehre and mathematics, the author has broken new ground that is at once stimulating, decidedly innovative, and elegantly audacious.” Professor Dr. Emmanuel Cattin. (shrink)

Many philosophers have taken there to be an important relation between personal identity and several of our practical concerns (among them moral responsibility, compensation, and self-concern). I articulate four natural methodological assumptions made by those wanting to construct a theory of the relation between identity and practical concerns, and I point out powerful objections to each assumption, objections constituting serious methodological obstacles to the overall project. I then attempt to offer replies to each general objection in a way that leaves (...) the project intact, albeit significantly changed. Perhaps the most important change stems from the recognition that the practical concerns motivating investigation into personal identity turn out to be not univocal, as is typically thought, such that each of the different practical concerns may actually be related to personal identity in very different ways. (shrink)

Agricultural decision making is characterized by two challenges common to multiple arenas: linking science to decision making and linking science and decision making across multiple levels. The U.S. agricultural research, education, and extension system was designed to address these challenges. By investigating this system, this study deepens the understanding of science and decision making, specifically exploring the notion of boundary organizations in two significant ways. First, it provides a preliminary test of the hypothesis that boundary organizations mediate between the shifting (...) domains of science and policy, finding that they are instrumental in creating and maintaining an integrated system of assessment and decision making for addressing depletion of the High Plains Aquifer. Second, it extends the concept of boundary organization beyond the science-policy dimension to incorporate the dimension of levels of organization—not only bridging science and policy but linking science and policy across different levels. (shrink)

Hannah Arendt's existential, republican concept of politics spurned Carl Schmitt's idea that enmity constituted the essence of the political. Famously, she isolated the political sphere from social conflict, sovereign regimes, and the realm of military violence. While some critics are now interested in applying Arendt's more abstract political ideas to international affairs, it has not been acknowledged that her original reconceptualization of politics was in fact driven by her analysis of global war, and in particular, the startling new challenges raised (...) by nuclear warfare. Arendt's early, unpublished manuscript on the nature of politics contains important reflections on the nature of war and empire. Surprisingly, these reflections tentatively explore the relationship between war and political freedom. A close reading of this work on war can help explain both her later, more radical non-violent concept of political action, and the difficulties she faced integrating her existential republicanism within the global context of conflict in the Cold War. (shrink)

Gadamer’s notion of dialogical truth relies on the claim that self and world “belong together” as aspects of a single, unitary phenomenon, one which is made manifest in language. This view has difficulty, however, accounting for that which is untruthful. To get past this obstacle I suggest that we turn to Nishida’s work, which shows how we can bring self and world together into a kind of harmony such that the cultivation of perception makes possible truthful expression.

This paper defends the permissibility of stem cell research against a theological objector who objects to it by appealing to "souls.".

Despite the importance of linguistic disclosure for philosophical hermeneutics there has been a conspicuous lack of attention to the question of how linguistic disclosure actually works. I examine the mechanics of disclosure by drawing on Gadamer’s philosophical hermeneutics as well as Ricoeur’s concept of translation and his theory of metaphor. My claim is that the background horizon of the unsaid that differs between languages enables each to disclose different things. This situation underscores the importance of engaging in East-West comparative philosophy, (...) of philosophizing across what Ricoeur calls the radical “fold” (pli) in what can be thought and experienced. (shrink)

This essay critically develops Watsuji’s nondual ontology of the self. Watsuji shows that the self is constituted by its relational contact with others and by its immersion in a wider geo-cultural environment. Yet Watsuji himself had difficulty in smoothly bringing together and integrating these notions. By showing how these domains work together to constitute the self, I bring into view the unity at the ground of Watsuji’s thought and the implications of this account for key ideas in Heidegger’s philosophy and (...) for environmental ethics. (shrink)

The interest in and enthusiasm for urban agriculture (UA) in urban communities, the non-profit sector, and governmental institutions has grown exponentially over the past decade. Part of the appeal of UA is its potential to improve the civic health of a community, advancing what some call food democracy. Yet despite the increasing presence of the language of civic agriculture or food democracy, UA organizations and practitioners often still focus on practical, shorter-term projects in an effort both to increase local involvement (...) and to attract funding from groups focused on quantifiable deliverables. As such, it seems difficult to move beyond the rhetoric of food democracy towards significant forms of popular participation and deliberation within particular communities. In this paper we provide a theoretical framework—deep democracy—that helps to contextualize nascent attempts at civic agriculture or food democracy within a broader struggle for democratic practices and relationships. We argue that urban agriculture efforts are well positioned to help citizens cultivate lasting relationships across lines of difference and amidst significant power differentials—relationships that could form the basis of a community’s collective capacity to shape its future. We analyze the theory of deep democracy through recent experiences with UA in Denver, Colorado, and we identify ways in which UA can extend its reach and impact by focusing more consciously on its political or civic potential. (shrink)

Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their capacity (...) to drive non‐adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This “epi‐transposon hypothesis” can not only explain macroevolutionary tempo and mode, but may also resolve other long‐standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge. (shrink)